ABSTRACT
Sodium carboxymethyl cellulose is an excellent pharmaceutical excipient. It possesses good filmability, mucoadhesiv-ity, viscolising capacity and bindability. The current aim of our research work is to synthesize a novel colon targeting polymer by using sodium carboxymethyl cellulose and glycine for colon targeting and to screen its colon specificity by in-vitro release model. Sodium carboxymethyl cellulose was subjected for synthesizing its derivative with glycine using azo linkage. The azo polymeric conjugate was evaluated for its color, solubility, Rf value, melting point, IR and 1HNMR spectral analysis. It was further subjected for evaluating its colon targeting property by in-vitro method using rat fecal matter. The research study revealed that the sodium carboxymethyl cellulose azo derivative showed promising colon specificity for a period of 120 minutes in a controlled manner along with modified solubility. So it can serve as a potential colon targeting polymer.
ABSTRACT
Sodium carboxymethyl cellulose is an excellent pharmaceutical excipient. It possesses good filmability, mucoadhesiv-ity, viscolising capacity and bindability. The current aim of our research work is to synthesize a novel colon targeting polymer by using sodium carboxymethyl cellulose and glycine for colon targeting and to screen its colon specificity by in-vitro release model. Sodium carboxymethyl cellulose was subjected for synthesizing its derivative with glycine using azo linkage. The azo polymeric conjugate was evaluated for its color, solubility, Rf value, melting point, IR and 1HNMR spectral analysis. It was further subjected for evaluating its colon targeting property by in-vitro method using rat fecal matter. The research study revealed that the sodium carboxymethyl cellulose azo derivative showed promising colon specificity for a period of 120 minutes in a controlled manner along with modified solubility. So it can serve as a potential colon targeting polymer.